Serum sickness

Other Names:
Accidental poisoning by blood products
Intoxication by serum
Protein illness
Serum rash

Serum sickness in humans is a reaction to proteins in antiserum derived from a non-human animal source, occurring 5–10 days after exposure. It is a type of hypersensitivity, specifically immune complex hypersensitivity (type III). The term serum sickness–like reaction (SSLR) is occasionally used to refer to similar illnesses that arise from the introduction of certain non-protein substances, such as penicillin. It was first characterized by Clemens von Pirquet and Béla Schick in 1906.


Serum sickness is an adverse reaction to blood product transfusion during surgery.

Related Problems:
Type B viral hepatitis
Related UN Sustainable Development Goals:
GOAL 12: Responsible Consumption and Production
Problem Type:
G: Very specific problems
Date of last update
22.06.2016 – 04:28 CEST