The major complications with Type 2 diabetes can be put into two groups: microvascular and macrovascular, or small-vessel complications and large-vessel complications. The microvascular complications include: diabetic retinopathy, which is diabetic eye disease; diabetes nephropathy, which is diabetic kidney disease; and also diabetes neuropathy, the nerve damage typical of type 2 diabetes. Macrovascular complications include: heart disease and stroke and other significant circulatory problems, such as peripheral vascular disease, meaning low circulation to the limbs. The micro vascular complications is significantly related to the high blood sugar. The large-vessel diseases have a variety of causes, including high blood sugar but they are more related to characteristics of the metabolic syndrome, such as high cholesterol, high triglycerides, low HDL.