Liver failure is the inability of the liver to perform its normal synthetic and metabolic functions as part of normal physiology. Two forms are recognised, acute and chronic (cirrhosis). Recently, a third form of liver failure known as acute-on-chronic liver failure (ACLF) is increasingly being recognized.
More than half of liver failure events caused by drug overdose and 20 percent of liver transplant surgeries are caused by acetaminophen (about 8,000 liver transplants occur every year in the U.S.).