Charcot-Marie-Tooth disease

Charcot-Marie-Tooth disease (CMT)is actually a broad term used to describe a group of genetic disorders that affects the peripheral nerves, which carry motor (relating to movement) and sensory (relating to sensation) signals between the brain and spinal cord and the rest of the body. CMT most frequently affects the lower legs, feet and hands, resulting in weakness and atrophy, or loss of muscle bulk, as well as causing a mild degree of loss of sensation. However, the motor problems are much more significant than the sensory problems, which are usually minor.

About one in 2,500 people has a form of CMT. Overall, it affects about 100,000 to 125,000 people in the USA alone, making it one of the most common hereditary disorders.