Manipulation of nicotine levels in tobacco

High-nicotine tobacco
Genetically manipulated tobacco
Increased nicotine in tobacco

Nature

Evidence has emerged in the US Justice Department investigation of the tobacco industry of companies deliberately increasing nicotine levels in tobacco to increase their addictiveness to smokers.

Incidence

In 1998 the US Justice Department brought the first criminal action accusing a biotechnology company of engaging in a scheme with a major cigarette maker to produce tobacco that has twice the nicotine level of the regular leaf. The biotechnology company was charged with misdemeanor conspiracy to export genetically engineered seeds capable of yielding the high-nicotine tobacco. The genetically engineered tobacco code-named Y-1, which cannot be grown in the US because federal regulations bar domestic production of tobacco with enhanced levels of nicotine, was being grown in Brazil and other foreign countries. While the company argued the goal of the project was not to strengthen nicotine levels but to maintain standard levels through blending, the US Justice Department charged that the aim of the conspiracy was to produce high-nicotine tobacco for use in manipulating cigarette nicotine strength.

Claim

Cigarette labels may mislead consumers to underestimate the amount of nicotine they actually receive. Current approaches to characterizing tar and nicotine yields of cigarettes are simplistic and misleading to consumers and regulators alike.

Machine-smoked nicotine yields of cigarettes are poor predictors of nicotine intake in smokers. One study found that individuals who smoke low-yield cigarettes received a nicotine exposure eight times greater than that recorded by the smoking machines. Instead of receiving the 0.14 milligram of nicotine recorded by the smoking machine, these individuals received on average 1.17 milligrams per cigarette smoked, while the labels of low-nicotine cigarettes commonly state the nicotine content as 0.1 milligram. Smokers of high-yield cigarettes had an intake that was 1.4 times the machine-smoked amount. These individuals inhaled on average 1.3 milligrams of nicotine per cigarette compared to the 0.91 milligram recorded by the smoking machines and the 1 milligram that appears on the package label of regular brands.