The most serious dietary deficiencies are: protein-calorie malnutrition (because of its high mortality rate, its wide prevalence and the irreversible physical and mental damage it may cause); xerophthalmia, vitamin A deficiency, (because of its contribution to mortality of malnourished children, its relatively wide prevalence and the dramatic irreversible damage it causes, namely blindness); nutritional anaemias, iron deficiency anaemia and megaloblastic anaemias (because of their wide distribution, their contribution to mortality from many other conditions and their effects on working capacity); endemic goitre, iodine deficiency, (because of its wide distribution). In some specific areas of the world, other nutritional problems such as beriberi, vitamin B1 deficiency; pellagra, nicotinic acid deficiency associated with protein deficiency; or rickets, vitamin D deficiency, may be of considerable importance.