Many TEN cases have occurred during treatment with high doses of corticosteroids for preexistent disease. The most extensive study of medication use and SJS-TEN mainly pointed to antibacterial sulfonamides, anticonvulsant agents, some nonsteroidal anti-inflammatory drugs and allopurinol. HIV infection dramatically increases the risk. A predisposing effect of autoimmune disorders, such as systemic lupus and an HLA-linked genetic susceptibility have been also suggested.