Sponsor biased research
Conflict of interest between pure and applied science
Corrupting effect of valuable prizes on academic integrity
Biased commercial research
Expertise biased in favour of the commissioning body
Research sponsored by vested interests
Manipulation of scientific studies
The size of individual research projects has long outgrown the means of individual researchers or private patrons. The aggregate scale of science has become a significant item in a national budget. Its products have nearly immediate cash value as inputs to industry. Under these circumstances, control over the choice of problems, evaluation of conclusions, and the use made of results inevitably passes to those who fund such industrial-scale enterprise. This transition from academic to industrialized science, and the sensitivity to sponsorship which researchers must acquire, can destroy the morale necessary for their creativity. The direction and character of science is being altered, even deformed, by political and commercial forces. The research profession is no longer motivated by "noblesse oblige" and a public-spirited elite is being replaced by a narrowly self-interested elite. This is corrupting the very foundations of modern scientific endeavour, and how the scientific and intellectual validity of "evidence-based" scientific research could be threatened by selfish, "money-driven" professionals/institutions.
Successful research attracts the bigger grant which makes further research impossible.