Medicines causing birth defects
Congenital malformations arising from pharmaceutical use
Use of isotretinoin during pregnancy has produced a cluster of birth defects, typically ear dysplasia, brain malformations, and heart defects. Griseofulvin has been linked to conjoined twinning and stillbirth in the USA. Certain anticonvulsant drugs used by epileptic mothers may increase the risk of congenital malformations. A particular concern is that of valporic acid with spina bifida.