Both the medical and dependence-producing properties of opium are derived from its main constituents, morphine and codeine. These two substances, together with morphine-like substances of synthetic origin, have taken over opium's therapeutic role. Both the natural and the synthetic groups of narcotics include substances with varying degrees of desirable and undesirable effects, all of which are abused as prescription and non-prescription drugs to some degree.
It was the international concern over the abuse of opium and the opioids that led to the formulation of the first international treaty on narcotics control -- the [International Opium Convention], signed at The Hague in 1912 (coming into force in 1915). Synthetic opiates with strong morphine-like effects were developed in the late 1930's, with a view to obtaining a strong but non-addictive analgesic which could be used to alleviate pain. Several synthetic alternatives now exist, but scientific research continues to seek an effective analgesic that produces all the beneficial effects of morphine and its derivatives without causing dependency.