Vaccine enhanced disease (VED)

"Immune enhancement response" describes a situation where the person vaccinated against a disease becomes ill immediately following vaccination. This could happen because of contaminants in the vaccine (including contamination by residues of non-target organisms) or the effects of prior vaccines given to the individual ("cross-reaction") or an unintended stimulation of the immune system (such as re-activation of a "silent" retrovirus in the individual) or by some other mechanism or combination of effects. Official government agencies which regulate, authorize and promote vaccines have made little attempt to clarify such issues. In part, this unwillingness has raised a distrust of vaccination.

Paradoxical immune enhancement (aka pathological priming, immune fixation, antigenic fixation, immunological imprinting, antibody dependent enhancement (ADE) and several other names) is a term used when a vaccine enhances susceptibility to severe illness and death, which expresses when the vaccinated person is subsequently infected with the actual disease-causing virus. In other words, the disease is enhanced by the prior vaccination for the same virus. The repeatedly vaccinated accumulate an array of antibodies designed for other viruses, or their variants, a situation which may allow a related virus to “escape” the immune response and cause infection.  So under ADE, the vaccine-generated antibodies are ineffective ("non-neutralizing") and let viruses enter cells rather than keep them out.  This has something to do with the stimulation of "binding antibodies"  as opposed to "neutralizing antibodies".

An "as yet unexplained" phenomenon, also known as vaccine enhanced disease (VED), produces an immune system overreaction -- a "cytokine storm" -- when the test subjects (in past trials both children or animals) that previously responded well to the vaccination were then exposed to the wild version of the virus.

Under "immune refocusing", the immune system is hobbled, “decoyed” into responding in ineffective ways. Also called "cell-based enhancement", this is a different category of paradoxical immune enhancement in which the vaccine-primed immune system launches a shoddy response to a subsequent natural infection.

"Immune imprinting" occurs when previous infections or vaccinations leave such a strong immune memory that the body continues to produce immune cells and antibodies targeting the previous immune experience—even when exposed to a new variant or vaccine.  This could be a problem if the person was unable to mount a useful immune response against a new variant

"Immune tolerance" occurs when the immune system becomes unresponsive to an antigen, or a particle that is causing disease. Excessive exposure to, say, the spike protein of SARS-Cov-2, as occurs with repeated vaccination, can induce "class switching" of antibodies to IgG4 and IgG2, downregulating resistance and permitting extended viral persistence.

For some vaccinations and diseases, mass vaccinations of a population can drive viral evolution so that the virus evades the existing vaccines. In the scientific literature this process is called “vaccination-induced evolutionary pressure” and leads to a phenomenon called “vaccine escape”.

Since the 1960s, tests of vaccine candidates for diseases such as dengue, respiratory syncytial virus (RSV) and severe acute respiratory syndrome (SARS) have shown a paradoxical phenomenon: Some animals or people who received the vaccine and were later exposed to the virus developed more severe disease than those who had not been vaccinated. In animal studies of SARS, aged mice were found to have particularly high risks of life-threatening Th2 immunopathology.

Clinical trials in 2014 of the dengue fever vaccine Dengvaxia elicited a very positive, favourable, antibody response in several hundred thousand children in the Philippines. On this basis, the vaccine was affirmed as part of a national campaign to eliminate dengue. However, when the vaccinated children subsequently actually contracted dengue, many got very sick and 600 died. The vaccine manufacturer, Sanofi, disclosed in 2017 that it was aware that the vaccine could cause more serious cases if given to patients without a prior dengue infection, at which point the Filipino government cancelled the campaign, sought a refund of costs from the vaccine manufacturer and is prosecuting criminally the local agencies and individuals involved in the decision-making.

The covid injections give the cells throughout the body a recipe to make a foreign protein (known as the spike protein). The body then makes antibodies and T cells to fight this foreign protein; the abundance of spike protein keeps the body in a constant state of inflammation and the immune system busy, reducing the ability of the immune system to respond to other infections—i.e., it suppresses the immune system and people are effectively immunocompromised and susceptible to infections, cancers, autoimmune disease.

Another mechanism is thought to be that the spike protein-preoccupied immune system overreacts when exposed to a similar pathogen, and one gets the release of cytokines and an allergic/anaphylactic type of reaction. There are other mechanisms of harm too, for example, chronic multi system inflammatory processes cause inflammation of the lining of blood vessels leading to blood clots, bruising and bleeding, and other vascular disorders.