Other Names:
Mauve factor
Pyrole disorder
Pyrrole disease

Pyroluria is a metabolic condition that is very rarely recognized by western medicine. It is considered by many in the functional medicine world "the most common unknown disorder". Pyroluria is a genetically determined chemical imbalance involving an abnormality in hemoglobin synthesis. The symptoms of pyroluria include chronic anxiety, poor stress tolerance, digestive issues, poor immunity, joint pain, acne or eczema, mood swings and poor short term memory. These individuals often have difficulty digesting and absorbing protein and they are easily wrecked by increasing stress. Pyrolurics need a specific diet, lifestyle and supplementation program to get well.


Pyroluria is a genetic condition that is typically related to familial alcoholism and/or environmental toxicity. If an individual has a family history of alcoholism they may very well have this genetic mutation. It can be induced with childhood trauma or a chronic infection early in life. The onset usually begins in the late teens and is often triggered by a traumatic life event.

Some researchers in the orthomolecular medicine and orthomolecular psychiatry believe that up to 10 percent of the population has pyroluria. It is estimated that as many as 50 percent of those with autism, 40 percent of alcoholics, 70 percent of schizophrenics, 70 percent of depressed individuals and 30 percent of people with ADHD have pyroluria.

Related UN Sustainable Development Goals:
GOAL 3: Good Health and Well-being
Problem Type:
G: Very specific problems
Date of last update
17.10.2021 – 10:56 CEST