Velocardiofacial syndrome (VCFS), also known as Shprintzen syndrome, is one of the most common genetic disorders in humans. It is caused by a deletion of a small segment of chromosome 22. Velocardiofacial syndrome has been associated with over thirty different features. The name velocardiofacial syndrome comes from the Latin words "velum" meaning palate, "cardia" meaning heart and "facies" having to do with the face. Not all of these identifying features are found in each child who is born with VCFS. The most common features are cleft palate (opening in the roof of the mouth), heart defects, characteristic facial appearance, minor learning problems and speech and feeding problems.