Diethylstilbestrol, a synthetic oestrogen, was prescribed to millions of pregnant women in the world from 1948. It was withdrawn in the USA in 1971. Up until 1979, it was prescribed as DistilbÃ¨ne in France, where 160,000 children of these women have been affected with congenital disorders. One of the most frequent effects on "DES-daughters" is hypertrophy of the uterine muscle, thus deforming the uterus cavity into particular forms, the most common being a "T". Some of the French 80,000 DES daughters are suffering from infertility.