Leaky gut syndromes are clinical disorders associated with increased intestinal permeability. They include inflammatory and infectious bowel disease, chronic inflammatory arthritide, cryptogenic skin conditions like acne, psoriasis and dermatitis herpetiformis, many diseases triggered by food allergy or specific food intolerance, including eczema, urticaria, irritable bowel syndrome, AIDS, chronic fatigue syndrome, chronic hepatitis, chronic pancreatitis, cystic fibrosis and pancreatic carcinoma.
When undigested proteins end up in the bloodstream, they are considered as “foreign” by the immune system. The resulting immune response is similar to what happens when the body mobilizes its defenses (i.e. T cells, B cells and antibodies) to eradicate a viral or bacterial infection. This type of immune response against proteins we eat contributes to food allergies. A similar mechanism that is not fully understood predisposes people with a leaky gut to develop more serious autoimmune disorders such as lupus, rheumatoid arthritis, type 1 diabetes, Graves disease, and inflammatory bowel disorders like Crohn’s and ulcerative colitis.