Other Names:
River blindness
Mal morado
Robles' disease

Onchocerciasis is a chronic infection of the skin and subcutaneous tissues caused by the filarial nematode (roundworm) Onchocerca volvulus. It is transmitted by the bite of blood-sucking female Simulium black flies found near rapid rivers. The biting vector black fly deposits the infective larvae beneath the skin of humans. The larvae penetrates the human tissue and, after about 1 year, develops into an adult worm. This is when symptoms of onchocerciasis can appear. Localized or generalized itching of the skin is common and may be severe. The result may be extensive scratching with skin abrasions and eruptions. Fibrous nodules or hard lumps appear in the skin. Fever, headache and tiredness may occur.

Apart from its generally debilitating effects, onchocerciasis frequently causes eye lesions leading to impairment of vision. Repeated superinfections result in blindness and also in a skin condition known as 'craw-craw', which causes intense itching. Resistance to certain larvacides renders the control of the vector flies a very difficult task. Moreover, water impoundment schemes have created new breeding places thereby intensifying endemicity.


The breeding and biting habits of the vector black fly influence the prevalence and type of infection. In Africa, the flies tend to bite low on the body and breed in fast-running streams and rivers. Eye lesions are more prevalent in the African savannah. Gross skin lesions are more prevalent in the rain forest. In America, the flies breed in very small streams. The vector black fly in Guatemala bites the upper body parts and results in great numbers of head nodules and eye lesions.


Onchocerciasis occurs in 34 countries of tropical Africa and the Americas, especially Mexico, Guatemala, Venezuela, northern Brazil and Colombia. At 1993, 18 million people were infected and a further 90 million were at risk. 90% of the infected people live in a wide belt south of the Sahara from Angola in the west to Tanzania in the east. In the Americas, important foci exist in Mexico, Guatemala, Colombia and Venezuela, and also among small human groups of the Amazonian forest. Blindness rates may attain dramatic proportions in heavily infected villages, particularly in the older age groups. In some areas up to 20% of villagers aged between 30 and 60 years are blind, and half the village ultimately goes blind. The greatest economic losses occur when horses and cattle are affected. In 1990 it was estimated that 40 million people were infected by leprosy, Chagas' disease and river blindness.

Related Problems:
Related UN Sustainable Development Goals:
GOAL 3: Good Health and Well-beingGOAL 14: Life Below Water
Problem Type:
E: Emanations of other problems
Date of last update
24.04.2019 – 12:35 CEST